Search for dissertations about: "Androgen receptor"

Showing result 1 - 5 of 96 swedish dissertations containing the words Androgen receptor.

  1. 1. Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Hannah Nenonen; Lunds universitet.; Lund University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgen receptor; polymorphism; CAG polymorphism; androgen receptor activity; infertility; prostate cancer; androgen receptor function;

    Abstract : The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. READ MORE

  2. 2. Genetic, environmental and life-style effects on androgen receptor function

    University dissertation from Lund University

    Author : Christel Björk; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

    Abstract : Popular Abstract in Swedish De senaste årtiondena har det diskuteras om det finns anledning till oro när det gäller mannens reproduktionsfunktion. Vissa forskningsresultat tyder på att spermieantalet har minskat och fler män har diagnostiserats med testikelcancer och medfödda missbildningar av könsorganen än tidigare. READ MORE

  3. 3. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    University dissertation from Umeå : Umeå University

    Author : Emma Jernberg; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Abstract : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). READ MORE

  4. 4. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation Special Focus on Vitamin D and Sex Hormones

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Lundqvist; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. READ MORE

  5. 5. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Kristina Lundin; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. READ MORE