Search for dissertations about: "Anesthetics"

Showing result 11 - 15 of 43 swedish dissertations containing the word Anesthetics.

2. 11. Transducer properties of a mechanoreceptor : an electrophysiological and pharmacological study of the crayfish stretch receptor

   Author : Jiahui Lin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : stretch receptor; Na channels; K channels; local anesthetics; calmodulin antagonist; patch clamp; voltage clamp;

   Abstract : The abdominal stretch receptor organ of the crayfish, an analog to the human muscle spindle, contains one slowly adapting (SA) and one rapidly adapting (RA) receptor neuron. The general aims of this project were to elucidate, in the SA and RA neurons, the participation of voltagegated Na+ and K+ channels in overall transducer process and adaptation, and to study possible blocking agents specific to mechanosensitive (MS) channels. READ MORE

4. 12. On paediatric regional anaesthesia : the use of paravertebral blockade, aspects on plasma protein binding, and systemic toxicity of local anaesthetics

   Author : Per-Arne Lönnqvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Anesthesia; regional; paravertebral Children; infants Local anesthetics; bupivacaine; lidocaine Pharmacokinetics Plasma protein binding Side effects Toxicity.PA Lönnqvist: On paediatric regional anaesthesia: The use of paravertebral blockade; aspec;

   Abstract : Paediatric regional anaesthesia has gained widespread popularity during recent years because of an excellent potential for intra- and postoperative pain relief and reduction of the surgically induced stress response. The aim of the present thesis was to adapt and develop the technique of paravertebral blockade (PVB) for the safe use in paediatric patients and also to investigate aspects on plasma protein binding and toxicity of local anaesthetic drugs which might be of importance in the special settings of paediatric anaesthesia. READ MORE

5. 13. Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics

   Author : Moritz Andreas Kretzschmar; Anders Larsson; Jan Jakobsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anesthesia; Animal models in research; Mass spectrometry; Gas chromatography; MIGET; Ventilation-perfusion; Desflurane; Isoflurane; Bronchoconstriction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Abstract : The mismatching of alveolar ventilation and perfusion (VA/Q) is the major determinant of impaired gas exchange. The gold standard for analyzing VA/Q distribution is the multiple inert gas elimination technique (MIGET), conventionally based on gas chromatography (GC), and, although simple in principle, a technically demanding procedure limiting its use. READ MORE

6. 14. System identification and control for general anesthesia based on parsimonious Wiener models

   Author : Margarida Martins da Silva; Torbjörn Wigren; Alexander Medvedev; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

   Abstract : The effect of anesthetics in the human body is usually described by Wiener models. The high number of patient-dependent parameters in the standard models, the poor excitatory pattern of the input signals (administered anesthetics) and the small amount of available input-output data make application of system identification strategies difficult. READ MORE

7. 15. Utility of bispectral index (BIS) monitoring during general anesthesia

   Author : Maj-Lis Lindholm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The possibility to objectively measure effects from anesthetics on the level of consciousness has since long been desired. General anesthetics cause changes in brain electrical activity, seen as changes in the electroencephalogram (EEG). READ MORE