Search for dissertations about: "Aneuploidy"

Showing result 1 - 5 of 56 swedish dissertations containing the word Aneuploidy.

  1. 1. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster

    University dissertation from Umeå : Umeå Universitet

    Author : Lina Lundberg; Umeå universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genome-wide gene regulation; aneuploidy; buffering; HP1a; POF; SETDB1; Su var 3-9; MSL; roX; genetik; Genetics;

    Abstract : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. READ MORE

  2. 2. Mitotic aberrations in mammalian cells

    University dissertation from Stockholm : Institutionen för genetik, mikrobiologi och toxikologi

    Author : Anna Renglin Lindh; Stockholms universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aneuploidy; mitotic aberrations; chemical effects; human cancer; DNA repair; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik;

    Abstract : Almost all cancer cells are aneuploid showing the wrong chromosome number and often with structural aberrations. The degree of aneuploidy correlates with an increase of the severity of the disease and tumour cells with chromosomal instability are more prone to acquire resistance to chemotherapy than other cells. READ MORE

  3. 3. Somatic Genetic Variation in Children: from Mosaicism to Cancer

    University dissertation from Lund University, Faculty of Medicine

    Author : Anders Valind; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017-12-15]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic Mosaicism; Cancer; Tumor heterogeneity; Neuroblastoma; Wilms Tumor; Rhabdomyosarcoma; Aneuploidy;

    Abstract : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. READ MORE

  4. 4. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

    University dissertation from Lund University, Faculty of Medicine

    Author : Naveen Ravi; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic thyroid cancer; copy number alterations; somatic mutations; mutational signatures; DNA methylation analysis; Gene expression analysis;

    Abstract : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. READ MORE

  5. 5. Studies on in vitro fertilised human preembryos. Morphological and chromosomal aspects

    University dissertation from Göteborg

    Author : Thorir Hardarson; Göteborgs universitet.; Gothenburg University.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IVF; oocyte; embryo; blastocyst; human; FISH; aneuploidy;

    Abstract : The success rate of in vitro fertilisation (IVF) has gradually increased due to basic research in preembryonic biology and the introduction of new methods, both technical and medical. However, further research is needed to establish which preembryos are developmentally most competent in order to be able to maintain the pregnancy rate while only a single preembryo is being transferred. READ MORE