Search for dissertations about: "Angelica S I Loskog"
Found 3 swedish dissertations containing the words Angelica S I Loskog.
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1. Myeloid-Derived Suppressor Cells and Other Immune Escape Mechanisms in Chronic Leukemia
Abstract : Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, a minute chromosome that leads to the creation of the fusion gene BCR/ABL and the transcription of the fusion protein BCR/ABL in transformed cells. The constitutively active tyrosine kinase BCR/ABL confers enhanced proliferation and survival on leukemic cells. READ MORE
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2. Intratumoral CD40 stimulating therapy in patients with advanced cancer
Abstract : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. READ MORE
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3. LOAd703 and beyond : Advancing immunostimulatory gene therapy for cancer
Abstract : In the last decade, immunotherapy has come into the limelight of cancer treatments. Immunotherapy aims to stimulate the body’s own immune system to create or reinvigorate anti-tumor immune responses. READ MORE