Search for dissertations about: "Angiotensin II"

Showing result 1 - 5 of 139 swedish dissertations containing the words Angiotensin II.

  1. 1. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II

    Author : Petra Johannesson; Rob M. J. Liskamp; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Synthesis; Aldehyde; Cyclization; Peptide; Angiotensin II; Ang II; Bioactive Conformation; Solid Phase Peptide Synthesis; Dimethyl Acetal; Farmaceutisk kemi; Syntes; Aldehyd; Cyklisering; Peptid; Bioaktiv konformation; Fast-fas peptidsyntes; Dimetylacetal; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. READ MORE

  2. 2. Design and synthesis of -turn peptidomimetics : Applications to angiotensin II

    Author : Susanna Lindman; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; peptide synthesis; turn mimetics; molecular modelling; receptor binding affinity; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : This study addresses the issue of how to convert peptides into drug-like non-peptides while retaining the biological activity at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. Small bioactive peptides are in most cases conformationally flexible molecules. READ MORE

  3. 3. On angiotensin II receptor type 2 receptors in the small intestine

    Author : Sara Ewert; Göteborgs universitet; Göteborgs universitet; Gothenburg University; Göteborgs universitet; Gothenburg University; []
    Keywords : renin-angiotensin; angiotensin; small intestine; mucosa; epithelium; AT1; AT2; bradykinin; BK2 receptor; nitric oxide; iNOS; smooth muscle; contractility;

    Abstract : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. READ MORE

  4. 4. Angiotensin II Receptors in the Human Coronary Circulation and in Heart Failure

    Author : Emil Pantev; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Heart Failure; Human Coronary Arteries; Angiotensin II; AT receptors;

    Abstract : Angiotensin II (Ang II) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, heart failure and atherosclerosis. In this thesis, the efficacy and safety of Ang II receptor blockers (ARB) were evaluated. READ MORE

  5. 5. Angiotensin II receptors in the small intestine. Expression analyses and functional considerations

    Author : Emma Spak; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : renin-angiotensin system; angiotensin II; AT1; AT2; small intestine; jejunum; hypovolemia; small bowel transplantation; smooth muscle; contractility;

    Abstract : .... READ MORE