Search for dissertations about: "Anna Lobell"
Found 5 swedish dissertations containing the words Anna Lobell.
-
1. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis
Abstract : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. READ MORE
-
2. Immunological Studies using Human and Canine Model Disorders
Abstract : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. READ MORE
-
3. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications
Abstract : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. READ MORE
-
4. Initiation of Autoimmunity in Experimental Autoimmune Encephalomyelitis
Abstract : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. READ MORE
-
5. DNA Sequence Variants in Human Autoimmune Diseases
Abstract : Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). READ MORE