Search for dissertations about: "Anna-karin L Robertson"

Found 1 swedish dissertation containing the words Anna-karin L Robertson.

2. 1. T cells in atherogenesis

   Author : Anna-Karin L Robertson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : atherosclerosis; T cells; transforming growth factor-beta; CD4; low-density lipoproteins; Th1 Th2; hypercholesterolemia;

   Abstract : The work of this thesis aims to answer the following questions: (1) Which role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4 essential for the athero-protective effect mediated by immunization with oxidized LDL by adjuvant? (3) How does the antigenspecific T cell response to oxidized LDL influence lesion development? (4) Is there a general shift to Th2 responses in severe hypercholesterolemia? and finally (5) Which role does transforming growth factor-B (TGF-B)-signaling in T cells play in atherogenesis? ApoE-/-CD4-/- mice were used to study the effect of CD4 deficiency in atherosclerosis. The development of atherosclerosis was decreased with attenuated inflammation in apoE-/- mice lacking CD4+ cells compared to immunocompetent apoE-/-. READ MORE