Search for dissertations about: "Antagonist"

Showing result 11 - 15 of 539 swedish dissertations containing the word Antagonist.

  2. 11. Platelet-derived growth factor: recombinant isoforms, structure/function relationships and design of a potential antagonist

    Author : Arne Östman; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 12. Time dependency in the protection from myocardial injury after myocardial ischemia and reperfusion : new insights from experimental studies with the ultrashort-acting calcium antagonist clevidipine

    Author : Daisuke Segawa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myocardial ischemia; reperfusion; calcium antagonist; clevidipine; preconditioning; experimental studies; rat; pig.;

    Abstract : Interruption of the coronary blood flow causes myocardial ischemia and, after a critical time period, myocardial cell death. Accordingly, early reinstitution of arterial blood flow is necessary to minimize the damage. READ MORE

  5. 13. The pharmacokinetics and pharmacodynamics of clevidipine, a new ultrashort-acting calcium antagonist, in different animal species and man

    Author : Hans Ericsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Clevidipine is a new ultrashort-acting calcium antagonist of the dihydropyridine type developed for reduction and control of blood pressure in connection with cardiac surgery. The aim of this thesis was to characterise the in vitro hydrolysis rate of clevidipine in different biological matrices and the pharmacokinetics and pharmacodynamics in animal species and various human populations. READ MORE

  6. 14. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Author : Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Keywords : Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Abstract : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. READ MORE

  7. 15. Alpha-1-microglobulin: Innate defence against pathological oxidation

    Author : Magnus Gram; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-1-microglobulin; pathological oxidation; hemoglobin; heme; radiation; oxidation; ROS; hemoglobin and heme antagonist; radical scavenger;

    Abstract : Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. READ MORE