Search for dissertations about: "Antagonist"

Showing result 6 - 10 of 540 swedish dissertations containing the word Antagonist.

  2. 6. Modulation of cytokine production by mononuclear cells in allergic inflammation. The effects of allergen exposure and anti-inflammatory agents

    Author : Katarzyna Wosinska-Becler; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokines; seasonal allergy; kinetics; CysLTR1 antagonist; montelukast; rush immunotherapy; monocyte; basophil; eosinophil; NK cell; T cell;

    Abstract : In pollen-sensitized subjects, seasonal allergen exposure results in clinical allergic disease, which in affected tissues displays a morphological picture typical of chronic inflammation. The cellular responses to allergens include the production of inflammatory cytokines that can be examined in peripheral blood cells. READ MORE

  4. 7. Strategies in the rat gambling task : Individual differences in decision-making and associations to behavior, neurobiology and human strategies

    Author : Nikita Tjernström; Erika Roman; Barry Everitt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Behavior; copulatory test; decision-making; ethanol; gambling disorder; impulsivity; individual differences; Iowa gambling task; MALDI-MSI; multivariate concentric square field; neurobiology; novel cage; opioid antagonist; rat gambling task; resting-state fMRI; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Gambling disorder (GD) is a behavioral addiction characterized by persistent and recurrent gambling behavior that disrupts personal, social or professional life. Studies have revealed that GD shares many features with alcohol and substance use disorders, but little is known about potential unique features in GD and to what extent characteristics are shared. READ MORE

  5. 8. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

    Author : Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
    Keywords : Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

    Abstract : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. READ MORE

  6. 9. Pulmonary hypertension related to heart failure and hypoxia. Mechanisms, new treatment strategies and impact on mortality following heart transplantation. Experiences from Skåne University Hospital in Lund

    Author : Jakob Lundgren; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary hypertension; Left heart disease; Heart Transplantation; ADMA; Survival; Hemodynamics; Soluble guanylate cyclase; Endothelin receptor antagonist; L-Arginine; Hypoxic pulmonary vasoconstriction;

    Abstract : .... READ MORE

  7. 10. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Author : Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Keywords : AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Abstract : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. READ MORE