Search for dissertations about: "Anti diabetes"

Showing result 1 - 5 of 161 swedish dissertations containing the words Anti diabetes.

  2. 1. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression

    Author : Siti Maisharah Sheikh Ghadzi; Maria C. Kjellsson; Mats O. Karlsson; Sandra Visser; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

  4. 2. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

    Author : Alexander Balhuizen; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

    Abstract : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). READ MORE

  5. 3. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

    Author : Anna Zetterqvist; Diabetiska komplikationer; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

    Abstract : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. READ MORE

  6. 4. Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

    Author : Mozhgan Dorkhan; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; insulin secretion; glucagon test; insulin resistance; insulin glargine; insulin tolerance test; thiazolidinediones; natriuretic peptides; adiponectin; thyroid associated ophthalmopathy; proinsulin;

    Abstract : Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. READ MORE

  7. 5. Diabetes Mellitus at the Time for Diagnosis : Studies on Prognostic Factors

    Author : Mats Martinell; Jan Stålhammar; Johan Hallqvist; Mozhgan Dorkhan; Claes-Göran Östenson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; New-onset Diabetes Mellitus; socioeconomic position; epidemiology; diabetes complications; diabetic retinopathy; cellular immunology; diabetes classification; type 2 diabetes; latent autoimmune diabetes in adults LADA ; type 1 diabetes; Allmänmedicin; Family Medicine; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : The aim for this thesis was to identify prognostic factors for chronic diabetes complications that exist at the time of diabetes diagnosis.Low level of education (... READ MORE