Search for dissertations about: "Anti-tumor activity"

Showing result 1 - 5 of 59 swedish dissertations containing the words Anti-tumor activity.

2. 1. Synthesis of Bioactive Analogues of Marasmane Dialdehydes

   Author : Daniel Röme; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Cancer; Enantioselective synthesis; Totalsynthesis; Semisynthesis; Cytotoxicity; Anti-tumor activity; Isovelleraloids; Marasmic acid; Marasmane dialdehydes; Isovelleral;

   Abstract : The modification of drugs into pro-drugs is an attractive concept allowing you to tweak the chemical and physical properties of a drug without changing the original structure of the active compound. In principle, any compound possessing a preferred biological activity can be transformed into a pro-drug. READ MORE

4. 2. Distribution and Chemical Diversity of Cyclotides from Violaceae : Impact of Structure on Cytotoxic Activity and Membrane Interactions

   Author : Robert Burman; Ulf Göransson; Lars Bohlin; William Gerwick; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclotide; Violaceae; Viola; Cytotoxic; Mechanism; In vivo; Structure-activity; Membrane; Mass spectrometry; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

   Abstract : During the last decade there has been increased interest in the cyclotide protein family, which consist of a circular chain of approximately 30 amino acids, including six cysteines that form three disulfide bonds, arranged in a cyclic cystine knot motif. This thesis gives new insights in cyclotide distribution and occurrence in the plant family Violaceae, structure-activity relationships for cytotoxic effects, membrane disruption and adsorption on lipid membranes, and evaluates toxicity and anti-tumor activity in vivo. READ MORE

5. 3. Telomerase activity and its regulation in malignant hematopoietic cells

   Author : Dawei Xu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : hTERT mortalization malignancy activity telomerase regulation;

   Abstract : Telomerase, a multicomponent ribonucleoprotein, synthesizes TTAGGG telomeric repeats essential for the stability and integrity of chromosomes. Most normal human somatic cells exhibit undetectable telomerase activity. READ MORE

6. 4. Fatal attraction : NK cell migration toward and activity in solid tumors

   Author : Veronika Kremer; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Natural killer (NK) cells play a key role in tumor immunosurveillance due to their ability to induce apoptosis of tumor cells and produce pro-inflammatory cytokines, without prior immune sensitization. In particular, NK cells demonstrate potent anti-tumor immune responses against metastases and hematological malignancies. READ MORE

7. 5. NO, Immunosuppression and Tumor Immmunotherapy

   Author : Pontus Hegardt; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

   Abstract : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. READ MORE