Search for dissertations about: "Antibodies"

Showing result 16 - 20 of 1730 swedish dissertations containing the word Antibodies.

2. 16. Structural investigation of SOD1 aggregates in ALS : identification of prion strains using anti-peptide antibodies

   Author : Johan Bergh; Thomas Brännström; Stefan L. Marklund; Peter M. Andersen; Joakim Bergström; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; prion; motor neuron disease; neurodegeneration; strain; seeding; protein aggregation; transgenic mice; peptide antibodies; Neurology; neurologi;

   Abstract : Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative syndrome characterized by progressive degeneration of motor neurons that result in muscle wasting. The symptoms advance gradually to paralysis and eventually death. Most patients suffer from sporadic ALS (sALS) but 10% report a familial predisposition. READ MORE

4. 17. Studies on antibodies against phospholipids

   Author : Leopold Årfors; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulants; platelets; platelet activation; complement activation; endothelial cells; thromboxane; prostacyclin; acetylsalicylic acid.;

   Abstract : The main clinical features of the antiphospholipid syndrome (APLS) are arterial and venous thrombosis, repeated spontaneous abortions and thrombocytopenia. Diagnosed concomitant with an underlying disease the designation is secondary APLS; otherwise primary APLS. READ MORE

5. 18. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

   Author : Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

   Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE

6. 19. Recombinant Antibodies – Tools for building proteomic platforms

   Author : Anna Säll; Institutionen för immunteknologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody development; recombinant scFv antibodies; phage display; affinity proteomics; mass spectrometry;

   Abstract : This thesis, which is based on four original papers, covers different aspects of the evolvement and development of proteomic platforms and the construction of human synthetic antibody libraries for the isolation of antibody reagents has been very central. There is an accelerating need for technologies capable of providing proteomic analysis of high sensitivity with good accuracy and an overall broad coverage as well as for biomarker validation. READ MORE

7. 20. Immunological characteristics of recombinant fragments of the Plasmodium falciparum blood-stage antigen Pf332

   Author : Halima A. Balogun; Klavs Berzins; Lars Hviid; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Plasmodium falciparum; Pf332; antibodies; immunity; growth inhibition; Immunology; Immunologi; immunologi; Immunology;

   Abstract : Effective malaria vaccine might help improve control strategies against malaria, but the complexity of interactions between the parasite and its hosts poses challenges. The asexual blood stage P. falciparum antigen Pf332 has potentials as one of the proteins in understanding the complex host-parasite interactions. READ MORE