Search for dissertations about: "Antibody validation"

Showing result 26 - 30 of 34 swedish dissertations containing the words Antibody validation.

  2. 26. Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma

    Author : Karin Fjordén; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous disease. Identification of prognostic and predictive markers is important to design individualised and effective treatment strategies. READ MORE

  4. 27. Towards a deeper understanding of the human brain

    Author : Evelina Sjöstedt; Mathias Uhlén; Jan Mulder; Caroline Kampf; Elly Hol; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain; organization; RNA; classification; mapping; proteins; antibodies; Bioteknologi; Biotechnology;

    Abstract : Identifying the proteome variation in different parts of the body provides fundamental molecular details, enabling further findings and mapping of tissue specific proteins. By combining quantitative transcriptomics with qualitative antibody based proteomics, the Human Protein Atlas (HPA) project aims to protein profile each human protein-coding gene. READ MORE

  5. 28. Biomarkers and viral risk factors in multiple sclerosis

    Author : Jesse Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease resulting in axonal injury and demyelination of nerve fibers in the central nervous system. The causal factor and pathological mechanisms governing disease progression have remained elusive, limiting the available clinical tools for MS diagnosis and treatment monitoring, particularly in the periphery. READ MORE

  6. 29. A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

    Author : Venera Kuci; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; side population; deoxycytidine kinase; resistance; SOX11; mantle cell lymphoma;

    Abstract : Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. READ MORE

  7. 30. Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer : biology and clinical implications

    Author : Ioannis Zerdes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling axis, immune-related gene signatures and immune cell subpopulations needs to be fully elucidated while the identification of prognostic and predictive biomarkers in BC is of utmost importance. READ MORE