Search for dissertations about: "Antigen-Presenting Cells"
Showing result 1 - 5 of 169 swedish dissertations containing the words Antigen-Presenting Cells.
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1. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells
Abstract : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. READ MORE
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2. TRAPC : a novel triggering receptor expressed on antigen presenting cells
Abstract : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. READ MORE
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3. Specific targeting of antigen-presenting cells for immunotherapy
Abstract : Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. READ MORE
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4. Peripheral immunity in patients with autoimmune endocrine diseases and the influence of physiological adaptions during pregnancy
Abstract : Type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), Graves’ disease (GD), and autoimmune Addison’s disease (AD) appear to share immunogenetic mechanisms. This idea is not novel, as “autoimmune tautology” is an established concept. READ MORE
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5. Antigen presenting cells in autoimmune diabetes: phenotype, function and modulation by Linomide
Abstract : The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. READ MORE