Search for dissertations about: "Antimalarial"

Showing result 1 - 5 of 53 swedish dissertations containing the word Antimalarial.

  1. 1. Organometallic complexes with antimalarial properties

    University dissertation from Department of Chemistry, Lund University

    Author : Lotta Glans; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganometallic chemistry; Chloroquine; Antimalarial; Drug resistance; Organometallic; Arene;

    Abstract : Malaria is a serious disease that causes around 800 000 deaths per year. Current malaria control efforts are hampered by the widespread resistance to common antimalarial drugs, such as the 4-aminoquinoline derivative called chloroquine. READ MORE

  2. 2. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Niklas Lindegårdh; Uppsala universitet.; Högskolan Dalarna.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; analytisk kemi; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi;

    Abstract : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. READ MORE

  3. 3. Modelling and Simulation to Improve Antimalarial Therapy

    University dissertation from Upppsala : Acta Universitatis Upsaliensis

    Author : Jesmin Permala Lohy Das; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE

  4. 4. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    University dissertation from Upppsala : Acta Universitatis Upsaliensis

    Author : Sofia Friberg Hietala; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

  5. 5. Clinical Pharmacokinetics of the Antimalarial Artemisinin Based on Saliva Sampling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Toufigh Gordi; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Artemisinin; pharmacokinetics; saliva; HPLC; pharmacodynamics; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : Artemisinin is the parent compound of a novel family of antimalarials. Repetitive administrations of artemisinin to both healthy volunteers and malaria patients have been shown to result in decreased plasma concentrations of the compound, most probably due to an autoinduction of different CYP450 enzymes. READ MORE