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Showing result 1 - 5 of 57 swedish dissertations matching the above criteria.
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1. Organometallic complexes with antimalarial properties
Abstract : Malaria is a serious disease that causes around 800 000 deaths per year. Current malaria control efforts are hampered by the widespread resistance to common antimalarial drugs, such as the 4-aminoquinoline derivative called chloroquine. READ MORE
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2. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids
Abstract : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. READ MORE
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3. Development of field-adapted analytical methods for the determination of new antimalarial drugs in biological fluids
Abstract : .... READ MORE
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4. Modelling and Simulation to Improve Antimalarial Therapy
Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE
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5. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy
Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE