Search for dissertations about: "Antimalarial"

Showing result 11 - 15 of 57 swedish dissertations containing the word Antimalarial.

  2. 11. Pharmacokinetics, drug metabolism and clinical effects of the antimalarial artemisinin : Time-dependencies and modeling aspects

    Author : Ulrika Sigrid Helena Svensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; Biofarmaci;

    Abstract : The mechanism behind artemisinin time-dependent bioavailability was investigated using a rat in-situ single-pass jejunal perfusion technique. The consequence for drug combination therapy was studied in healthy volunteers and in patients with Plasmodium falciparum. READ MORE

  4. 12. Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy

    Author : Daniel Röshammar; Göteborgs universitet; []
    Keywords : HIV; malaria; pharmacokinetics; pharmacodynamics; pharmacometrics; NONMEM;

    Abstract : HIV/AIDS and malaria are two major global infectious diseases. Although better drugs against these conditions are becoming more available, dosages may not always be optimal with respect to effectiveness, safety, cost or convenience of administration. READ MORE

  5. 13. The molecular basis of Plasmodium falciparum resistance to the antimalarial lumefantrine

    Author : Christin Sisowath; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria control is compromised by the development and spread of Plasmodium falciparum resistance to antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. Artemisinin based combination therapy (ACT) has been implemented in almost all malaria endemic areas in an attempt to suppress drug resistance. READ MORE

  6. 14. Role of PfATP6 and pfMRP1 in Plasmodium falciparum resistance to antimalarial drugs

    Author : Sabina Dahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Half of the world's population live at risk for malaria and nearly one million people die from the disease every year. The malaria burden is greatest in children and pregnant women in sub-Saharan Africa. READ MORE

  7. 15. Factors Influencing Evolution to Antimalarial Drug Resistance in Plasmodium falciparum in Sudan and The Gambia

    Author : Amany Kheir; Göte Swedberg; Susanne Kerje; Hamza Babiker; Staffan Svärd; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cross-mating; fitness; microsatellite haplotypes; mosquito infectivity; Infectious diseases; Infektionssjukdomar; Molekylär genetik; Molecular Genetics;

    Abstract : Drug resistance is a major obstacle to management and control of malaria and currently progressing at a rapid rate across Africa. This thesis has examined factors influencing evolution of resistant P. falciparum at two sites in Africa, including parasite migration, cross mating and fitness cost of resistance. READ MORE