Search for dissertations about: "Antimicrobial agents"

Showing result 1 - 5 of 61 swedish dissertations containing the words Antimicrobial agents.

  1. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  2. 2. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Author : Camilla Björn; RISE; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Abstract : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. READ MORE

  3. 3. Antimicrobial peptides in the treatment of infectious and inflammatory conditions - Preclinical studies of mechanism of action, efficacy, and safety

    Author : Camilla Björn; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Abstract : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. READ MORE

  4. 4. Carbon monoxide and nitric oxide as antimicrobial agents : focus on ESBL-producing uropathogenic E.coli

    Author : Charlotte Sahlberg Bang; Katarina Persson; Bo Söderquist; Annelie Brauner; Örebro universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biofilm; carbon monoxide; CORM-2; DETA NO; extendedspectrum beta-lactamases; nitric oxide; urinary tract infection; uropathogenic Escherichia coli; Biomedicin; Biomedicine;

    Abstract : Urinary tract infections (UTI) are common in humans and most often caused by uropathogenic Escherichia coli (E. coli). Extended-spectrum beta-lactamase (ESBL)-producing E. coli are increasing worldwide and they are frequently multidrug-resistant with limited treatment options. READ MORE

  5. 5. Antimicrobial and anti-inflammatory agents in experimental gingivitis

    Author : Satoshi Sekino; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The main objectives of the present series of experiment was to evaluate i) the microbial changes that occurred in plaque during de novo plaque formation, ii) the influence of the number of bacteria in saliva on de novo plaque formation, iii) the effect of a chlorhexidine regimen on the recolonization of bacterial species in plaque and saliva, iv) the effect of systemic administration of ibuprofen on gingivitis development and de novo plaque formation and v) the effect of a mouthrinse containing Listerine® on gingivitis development and de novo plaque formation.Subjects with no signs of periodontal disease were recruited. READ MORE