Search for dissertations about: "Antipsychotics effect"

Showing result 11 - 15 of 18 swedish dissertations containing the words Antipsychotics effect.

  2. 11. Depression in older people with and without dementia : non-pharmacological interventions and associations between psychotropic drugs and mortality

    Author : Gustaf Boström; Håkan Littbrand; Erik Rosendahl; Peter Nordström; Knut Engedal; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; Dementia; Exercise; Randomized controlled trial; Psychotropic drugs; Mortality; Gender; Residential facilities; Frail elderly; Epidemiology; Cohort study; geriatrik; Geriatrics; sjukgymnastik; Physiotherapy;

    Abstract : The aim of this thesis was to investigate associations between psychotropic drug use and death, associations between functional capacity, dependency in ADL and depression, and to evaluate a non-pharmacological intervention to reduce depressive symptoms, among older people with and without dementia.There is limited knowledge about the risk of death associated with psychotropic drug use among those aged ≥85 years, those with dementia, or those living in residential care facilities; groups that have a higher intake of psychotropic drugs and who are also more prone to adverse drug reactions. READ MORE

  4. 12. Communication and teamwork : Studies of the impact on quality of drug use in swedish nursing homes

    Author : Ingrid Schmidt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; nursing homes; elderly; drug use; psychotropics; quality; randomized controlled trial; multidisciplinary interventions; teams; communication; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : This thesis examines factors that affect the quality of drug-use practices in Swedish nursing homes.The analysis comprises six consecutive studies. READ MORE

  5. 13. Clinical molecular imaging of schizophrenia

    Author : Mirjam Talvik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; D2 D3 receptors; 5HT2A receptors; antipsychotic drugs; schizophrenia; age effects; raclopride; FLB 457; M100907; clozapine; haloperidol; perphenazine; thalamus; cortex; striatum; PANSS;

    Abstract : The aim of this thesis was to examine pathophysiology and antipsychotic treatment of schizophrenia by using positron emission tomography (PET). The high affinity radioligand [11C]FLB 457 was used for determination of dopamine D2 receptor binding in the thalamus and the cortex of nine drug-naïve patients with schizophrenia and eight control subjects. READ MORE

  6. 14. The toxicological pharmacoepidemiology of suicide : population-based studies on psychotropic-medication use in Sweden

    Author : Jonas Forsman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The act of completed suicide is a complex phenomenon associated with numerous identified individual and combined risk factors. Mental illness and related disorders confer among the highest risks of completed suicide and have consequently been targeted through pharmacological interventions. READ MORE

  7. 15. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

    Author : Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE