Search for dissertations about: "Antitumor immunity"
Showing result 1 - 5 of 8 swedish dissertations containing the words Antitumor immunity.
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1. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells
Abstract : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. READ MORE
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2. Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity
Abstract : CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective role in many tumor models, their ability to promote intestinal inflammation, known to enhance intestinal cancer, raised the question if they would be protective in intestinal tumor development. READ MORE
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3. Effect of IL-1beta secretion on lymphoid tissue and on antitumor immune responses
Abstract : Interleukin (IL)-1beta is one of the most pleiotropic and potent cytokines, produced predominantly by activated monocytes and macrophages. IL-1 plays an important role in normal immunoregulatory processes but also in pathophysiological inflammatory responses. In the present study, we developed a model for active IL-1beta secretion. READ MORE
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4. Immunological recognition and tumor escape mechanisms of ovarian carcinoma
Abstract : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. READ MORE
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5. Molecular and cellular strategies to enhance efficacy of T cell-based cancer therapy
Abstract : A combined approach of vaccination with β2-microglobulin (β2m)-deficient dendritic cells (DCs) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potent adjuvant may link cellular and molecular strategies to further enhance anti-tumor T-cell responses. T lymphocytes can mediate a potent anti-tumor immune response. READ MORE