Search for dissertations about: "Antitumor"

Showing result 11 - 15 of 64 swedish dissertations containing the word Antitumor.

  2. 11. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

    Author : Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

    Abstract : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. READ MORE

  4. 12. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

    Author : Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

    Abstract : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. READ MORE

  5. 13. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Author : Yinghua Zhou; Uppsala universitet; []
    Keywords : Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE

  6. 14. Novel approaches for cancer immunotherapy

    Author : Fredrik Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current cornerstones of our fight against cancer. READ MORE

  7. 15. Development of nanoscale delivery systems for breast cancer treatment

    Author : Yuning Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nanoparticle (NP) assisted diagnosis and drug delivery for antitumor applications have been widely investigated in the past few decades. To date, some of them have been approved for clinical applications and many more of them are under clinical trials. READ MORE