Search for dissertations about: "Antitumor"

Showing result 16 - 20 of 64 swedish dissertations containing the word Antitumor.

  2. 16. Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer

    Author : Tolga Sutlu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A century after the initial proposition that the immune system has the capacity to fight against tumors, evading destruction by immune cells is now well recognized as a hallmark of cancer. Recent decades have witnessed extraordinary improvements in the use of immunotherapy against malignancies and adoptive transfer of Natural Killer (NK) cells stands among promising tools in the fight against cancer. READ MORE

  4. 17. Effects of interferon on cellular proliferation and apoptosis

    Author : Olle Sangfelt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : interferon; malignancy; apoptosis; cell cycle;

    Abstract : Interferon (IFN) therapy is today a well-established treatment in many diseases, including various malignancies. How IFN exerts antitumor activity is not known, but several mechanisms have been suggested. READ MORE

  5. 18. Structure-Reactivity Correlations for Reactions of Palladium(II) and Platinum(IV) Complexes

    Author : Tiesheng Shi; Kemiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; thiol; l-methionine; maleic acid; carboxylic acid; thioether; platinum IV ; palladium II ; linear free energy relationship; volumes of activation; structure-reactivity correlation; reduction; substitution; equilibria; kinetics; mechanism; glutathione; Animal physiology; Djurfysiologi;

    Abstract : The kinetics and mechanism for substitution reactions on tetraaquapalladium(II) by an extended series of thioethers, a great number of carboxylic acids, and olefins have been studied by use of UV-VIS, stopped-flow, and high-pressure stopped-flow spectrophotometry and NMR spectroscopy. Second-order rate constants k and activation parameters (activation enthalpies, entropies, and volumes) for formation of monodentate 1:1 complexes have been determined. READ MORE

  6. 19. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?

    Author : Karin Staflin; CNS Genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; Glioma; sub ventricular zone; neural progenitor cell;

    Abstract : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. READ MORE

  7. 20. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

    Author : Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. READ MORE