Search for dissertations about: "Antonio Carlesso"
Found 1 swedish dissertation containing the words Antonio Carlesso.
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1. Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
Abstract : Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association of IRE1 dysregulation with a wide range of human diseases, stimulated research towards the discovery of small organic molecules able to modulate IRE1 signalling, and to potentially be used as novel therapeutics. READ MORE
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