Search for dissertations about: "ApcMin mouse"

Showing result 1 - 5 of 6 swedish dissertations containing the words ApcMin mouse.

  1. 1. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer

    Author : Zhiyuan V. Zou; Göteborgs universitet.; Gothenburg University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; ApcMin mouse;

    Abstract : Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or somatic mutations in the APC gene. READ MORE

  2. 2. Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity

    Author : Ying Wang; Göteborgs universitet.; Gothenburg University.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKT lymphocyte; intestinal tumor; CD1d; colrectal cancer; immunoregulation; α-gagactosylceramide;

    Abstract : CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective role in many tumor models, their ability to promote intestinal inflammation, known to enhance intestinal cancer, raised the question if they would be protective in intestinal tumor development. READ MORE

  3. 3. The role of CysLT1R in animal models of colorectal cancer

    University dissertation from Cell Pathology

    Author : Sayeh Savari; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Popular Abstract in Swedish Det finns ett starkt samband mellan kronisk inflammation och cancer. Ett av de mer etablerade sambanden är den mellan kronisk inflammation i tarmen och den i Sverige tredje vanligaste cancersjukdomen, nämligen tjocktarmscancer. READ MORE

  4. 4. Inflammation and host-microbe signaling in the development and progression of colorectal carcinoma

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Yinghui Li; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Gut microbiota play an integral role in the postnatal development and maturation of the intestinal epithelium as well as the innate and adaptive immune system. Gut microbes communicate to the host via pattern recognition receptors (PRRs) which regulate intestinal homeostasis during health and disease. READ MORE

  5. 5. Pathophysiological impact of targeting the ROS-p53 axis

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Volkan I. Sayin; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

    Abstract : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. READ MORE