Search for dissertations about: "Apoptosis drug effects"
Showing result 1 - 5 of 104 swedish dissertations containing the words Apoptosis drug effects.
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1. Apoptosis Regulation in Multiple Myeloma
Abstract : Multiple myeloma (MM) is a virtually incurable B cell malignancy of the bone marrow. One important part of tumor progression and an obstacle for successful therapy is resistance to apoptosis. To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. READ MORE
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2. Lysophosphatidic acid : Physiological effects and structure-activity relationships
Abstract : Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. READ MORE
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3. Bacterial toxins for cancer treatment
Abstract : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. READ MORE
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4. Activity and Regulation of Telomerase in Malignant Cells
Abstract : An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types. READ MORE
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5. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma
Abstract : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. READ MORE