Search for dissertations about: "Arne Elofsson"

Showing result 1 - 5 of 33 swedish dissertations containing the words Arne Elofsson.

  2. 1. Membrane-bound proteins : Characterization, evolution, and functional analysis

    Author : Misty M. Attwood; Helgi B. Schiöth; Arne Elofsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transmembrane protein; alpha-helical membrane protein; evolution membrane proteins; 3TM; 4TM; 5TM; trispanin; Bioinformatics; Bioinformatik;

    Abstract : Alpha-helical transmembrane proteins are important components of many essential cell processes including signal transduction, transport of molecules across membranes, protein and membrane trafficking, and structural and adhesion activities, amongst others. Their involvement in critical networks makes them the focus of interest in investigating disease pathways, as candidate drug targets, and in evolutionary analyses to identify homologous protein families and possible functional activities. READ MORE

  4. 2. Orphan Genes Bioinformatics : Identification and properties of de novo created genes

    Author : Walter Basile; Arne Elofsson; Diethard Tautz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; de novo; orphans; evolutionary genetics; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Even today, many genes are without any known homolog. These "orphans" are found in all species, from Viruses to Prokaryotes and Eukaryotes. For a portion of these genes, we might simply not have enough data to find homologs yet. READ MORE

  5. 3. Creation of new proteins - domain rearrangements and tandem duplications

    Author : Åsa Björklund; Arne Elofsson; Sarah Teichmann; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Abstract : Proteins are modular entities with domains as their building blocks. The domains are recurrent protein fragments with a distinct structure, function and evolutionary history. During evolution, proteins with new functions have been invented through rearrangements as well as differentiation of domains. READ MORE

  6. 4. Learning Protein Evolution and Structure

    Author : Patrick Bryant; Arne Elofsson; Paul Bates; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Evolution; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : By analysing the structure of a protein it is possible to draw conclusions about its function. Obtaining the structure of a protein experimentally is however a time consuming and expensive process. By using evolution it is possible to infer the structure of a protein. READ MORE

  7. 5. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

    Author : Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

    Abstract : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. READ MORE