Search for dissertations about: "Artesunate"

Showing result 1 - 5 of 12 swedish dissertations containing the word Artesunate.

  1. 1. In vitro and in vivo studies of artemisinin endoperoxides

    Author : Therese Ericsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artemisinin; Artesunate; Breast cancer; Cytochrome P450; Dihydroartemisinin; Inhibition; LC-MS MS; Pharmacokinetics; Plasma; Saliva;

    Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE

  2. 2. Plasmodium falciparum resistance to amodiaquine in monotherapy and in combination therapy with artesunate

    Author : Gabrielle Holmgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In response to the increasing resistance to antimalarial monotherapies, artemisinin basedcombination therapy (ACT) is now recommended as first line therapy against uncomplicatedPlasmodium falciparum malaria. However, the choice of partner drug to artemisinin (ART) iscritical for ACT efficacy to endure. READ MORE

  3. 3. Search for genetic determinants of Plasmodium falciparum malaria drug resistance in vitro and in vivo

    Author : Aminatou Kone; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria remains the most deadly disease in the world with nearly 627 000 deaths and more than 200 million new clinical cases every year, the large majority occurring in sub Saharan Africa children aged < 5 years. This represents anyway a significant decrease as compared with the situation in the start of the Millennium. READ MORE

  4. 4. Managing malaria in under-fives : prompt access, adherence to treatment and referral in rural Tanzania

    Author : Daudi Simba; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria;

    Abstract : Background: Nearly a million people die of malaria each year, the majority are children in rural African settings. These deaths could be reduced if children had prompt access to artemisinin-based combination therapy (ACTs), demonstrated adherence to treatment and to referral advice for severe malaria. READ MORE

  5. 5. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Author : Sofia Friberg Hietala; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE