Search for dissertations about: "Arwyn Jones"

Found 2 swedish dissertations containing the words Arwyn Jones.

  2. 1. Cell-penetrating peptides for oligonucleotide delivery : Design and uptake mechanisms

    Author : Staffan Lindberg; Ülo Langel; Arwyn Jones; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; gene therapy; scavenger receptors; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The use of oligonucleotides for gene therapy has the potential to efficiently treat a plethora of diseases with minimal side effects. However, the use of oligonucleotides is hampered by the properties of these molecules, which make it essentially impossible for them to permeate the cellular membrane. READ MORE

  4. 2. Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery

    Author : Jakob Regberg; Ülo Langel; Arwyn Tomos Jones; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; oligonucleotides; gene therapy; drug delivery; scavenger receptors; blood-brain barrier; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging from genetic disorders to viral infections and cancer. The problem is that efficient delivery across the cell membrane is required for oligonucleotides to have their desired effect. Cell-penetrating peptides (CPPs) provide a solution to this problem. READ MORE