Search for dissertations about: "Ash1"
Found 4 swedish dissertations containing the word Ash1.
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1. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression
Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE
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2. Jack of all trades, master of none : the multifaceted nature of H3K36 methylation
Abstract : Post-translational modifications of histones enable differential transcriptional control of the genome between cell types and developmental stages, and in response to environmental factors. The methylation of Histone 3 Lysine 36 (H3K36) is one the most complex and well-studied histone modifications and is known to be involved in a wide range of molecular processes. READ MORE
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3. Adenovirus for Cancer Therapy : With a Focus on its Surface Modification
Abstract : Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. READ MORE
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4. Dynamics of protein folding and subunit interactions in assembly of the yeast mediator complex
Abstract : The Mediator complex was originally discovered in the yeast Saccharomyces cerevisiae and has since then been shown to be required for transcriptional regulation both in vitro and in vivo. The Mediator complex also stimulates basal, unregulated transcription and serves as a bridge by conveying signals from promoter-bound transcriptional regulatory proteins such as activators and repressors to the RNA Polymerase II general transcriptional machinery. READ MORE