Search for dissertations about: "Atorvastatin"

Showing result 1 - 5 of 16 swedish dissertations containing the word Atorvastatin.

  1. 1. Analysis of risk factors in patients with severe chronic kidney disease. The role of atorvastatin

    Author : Benny Holmberg; Bernd G Stegmayr; Christer Andersson; Peter M Nilsson; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atorvastatin; cholesterol; chronic kidney disease; haemodialysis; cholesterol; lipids; peritoneal dialysis; risk factors; statins; inter dialysis weight gain;

    Abstract : Background and aim: There had been no randomized end-point studies with statins for patients with severe renal failure. The purpose of this prospective, open, randomized, controlled study was to investigate whether atorvastatin (10 mg/day) would alter cardiovascular end-points and the overall mortality rate of patients with chronic kidney disease stage 4 or 5 (creatinine clearanceMaterial & Methods: This was an open, prospective, randomized study. READ MORE

  2. 2. Atrial fibrillation : treatment, associated conditions and quantification of symptoms

    Author : Niklas Höglund; Steen Jensen; Milos Kesek; Karl Franklin; Juhani Koistinen; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrial fibrillation; cardioversion; atorvastatin; high-sensitivity C-reactive protein; symptoms; sleep apnea; Cardiology; kardiologi;

    Abstract : Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. There is a need for new pharmacological treatment strategies since the current antiarrhythmic drugs have a modest efficacy and may have severe side effects. Cardioversion (CV) of AF offers an opportunity to study related conditions in sinus rhythm (SR) and during AF. READ MORE

  3. 3. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man

    Author : Ott Saluveer; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : t-PA; hypertension; fibrinolysis; endothelial function; valproic acid; histone deacetylase inhibitor; atorvastatin;

    Abstract : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. READ MORE

  4. 4. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

    Author : Anna Vildhede; Per Artursson; Maria Karlgren; Maria Kjellsson; Ulf Norinder; Kim Brouwer; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

    Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE

  5. 5. Postprandial lipaemia and its relation to premature atherosclerosis in middle-aged men

    Author : Susanna Boquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; alimentary lipaemia; atherosclerosis; atorvastatin; coronary heart disease; intima-media thickness; triglyceride-rich lipoproteins;

    Abstract : The present research programme was set up to investigate whether pertubations of the metabolism of postprandial triglyceride-rich lipoproteins (TRLs) are related to premature atherosclerosis and to determine if treatment with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (atorvastatin) improves deranged alimentary lipaemia in postinfarction patients with combined hyperlipidaemia. The relation between plasma insulin and alimentary lipaemia was investigated as well. READ MORE