Search for dissertations about: "Atox1"

Showing result 1 - 5 of 6 swedish dissertations containing the word Atox1.

  2. 1. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Author : Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Abstract :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. READ MORE

  4. 2. COPPER BINDING PROTEINS IN BREAST CANCER : CELLULAR AND MOLECULAR MECHANISMS

    Author : Xiaolu Zhang; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atox1; Memo1; cell migration; breast cancer; copper; ROS;

    Abstract : Cancer is one of the leading causes of human death. However, the mechanisms governing cancer are still not fully understood. Elevated levels of copper (Cu) have been observed in both cancerous tissues and the serum of cancer patients. READ MORE

  5. 3. Roles of intermolecular interactions in amyloid fibril formation mechanisms

    Author : Tony Werner; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; disulfide-bonds; Atox1; α-synuclein; Aggregation; protein interactions; Parkinson’s disease; β-parvalbumin; macromolecular crowding; osmolytes; Amyloid fibrils;

    Abstract : Amyloid fibrils, a major pathological feature of several neurodegenerative disorders, are highly stable, insoluble aggregates of misfolded proteins. The formation of such aggregates involves a complex equilibrium between protein monomers, different on- and off-pathway transient oligomeric species, and amyloid fibrils. READ MORE

  6. 4. Engineering Yeast for Functional Analysis of Human Cu Transport Proteins

    Author : Kumaravel Ponnandai Schanmugavel; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cu transport; yeast model; Atox1; genetic engineering; Wilson disease protein; ATP7B; complementation assay; yeast growth; metal-binding domain; mechanisms.;

    Abstract : ABSTRACT       Copper (Cu) is an important trace element that plays a vital role in several biological processes. Many proteins that are involved in various biochemical pathways require Cu as a cofactor. READ MORE

  7. 5. Human copper ion transfer : from metal chaperone to target transporter domain

    Author : Moritz Sebastian Niemiec; Pernilla Wittung-Stafshede; Nigel Robinson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

    Abstract : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. READ MORE