Search for dissertations about: "Atypical hemolytic uremic syndrome"

Showing result 1 - 5 of 7 swedish dissertations containing the words Atypical hemolytic uremic syndrome.

2. 1. Clinical, epidemiological and molecular aspects of hemolytic uremic syndrome

   Author : Lisa Sartz; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; O157; C3; microparticles; Shiga toxin; epidemiology; EHEC; hemolytic uremic syndrome; complement; tissue factor; atypical HUS;

   Abstract : Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in the western world. HUS is characterized by the triad of hemolytic anemia, thrombocytopenia and renal failure. There are two main subtypes of HUS; typical or D+ (D stands for diarrhea) HUS associated with enterohemorrhagic E. READ MORE

4. 2. Platelet activation and tissue factor release in hemolytic uremic syndrome

   Author : Anne-lie Ståhl; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hemolytic uremic syndrome; platelets; tissue factor; LPS; Shiga toxin; complement system; factor H; clusterin;

   Abstract : Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. There are two subtypes: typical HUS associated with enterohemorrhagic E. coli (EHEC) and atypical HUS associated with uninhibited activation of the alternative pathway of complement. READ MORE

5. 3. Studies of the role of complement factor H in hemolytic uremic syndrome

   Author : Fariba Vaziri Sani; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; Hemolytic uremic syndrome; complement system; factor H;

   Abstract : Factor H is the main fluid phase regulator of the alternative pathway of complement. Factor H acts as a co-factor for factor I-mediated C3b degradation, inhibits the formation of the C3bBb convertase and accelerates its decay. By discriminating between host and foreign cells, factor H inhibits complement-mediated injury to host cells. READ MORE

6. 4. Studies of EHEC and the complement system in renal diseases

   Author : Zivile Békassy; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; hemolytic uremic syndrome; thrombotic microangiopathy; atypical hemolytic uremic syndrome; alternative pathway of complement; dense deposit disease; eculizumab;

   Abstract : This thesis addressed the diagnosis, pathogenesis and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). READ MORE

7. 5. Aspects of Complement Activation in Thrombocytopenic Disorders

   Author : Alexander Åkesson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thrombocytopenia; Complement activation; Complement dysregulation; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome; Platelet transfusion refractoriness;

   Abstract : The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. READ MORE