Search for dissertations about: "Autoimmune Disease in family"

Showing result 1 - 5 of 70 swedish dissertations containing the words Autoimmune Disease in family.

2. 1. Clinical and genetical aspects of Celiac Disease

   Author : Audur Gudjonsdottir; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; sib-pair; screening; genome-wide scan; linkage analysis; heritability; genotypes; DQ2-negative; phenotypes; autoimmune disease;

   Abstract : Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. READ MORE

4. 2. Human antibody repertoires in normal physiology and in autoimmune disease

   Author : Iris F van Dijk Härd; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The immune system has to balance the need for a broad protection from infectious agents against the risk of developing autoimmune disease. The elements of the immune system should provide clues about conditions under which physiological autoreactivity may develop into autoaggressive immunity, if analyzed against the background of the immune system in healthy individuals. READ MORE

5. 3. B cell repertoire development in normal physiology and autoimmune disease

   Author : Åsa Andersson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell repertoire; connectivity; natural antibodies; non-obese diabetic NOD ; Ig therapy; Vh7183 gene family;

   Abstract : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. READ MORE

6. 4. Immunogenetic studies in autoimmune endocrine diseases

   Author : Giovanni Gambelunghe; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Type I Diabetes; LADA; Addison s disease; HLA; MICA; MICB; autoantibodies;

   Abstract : Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterised by Tlymphocyte infiltration of islets of Langerhans with consequent destruction of beta cells. A permissive genetic background is required for the development of the islet autoimmune process. READ MORE

7. 5. Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases

   Author : Ludmila Prokunina; Marta Alarcon-Riquelme; Ulf Gyllensten; Juha Kere; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; complex diseases; autoimmune diseases; genetic mapping; functional studies; Genetik; Clinical genetics; Klinisk genetik;

   Abstract : Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1. READ MORE