Search for dissertations about: "Avdelningen för klinisk genetik"
Showing result 1 - 5 of 75 swedish dissertations containing the words Avdelningen för klinisk genetik.
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1. MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
Abstract : The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. READ MORE
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2. Genetic Characterization of Bone and Soft Tissue Tumors
Abstract : Bone and soft tissue tumors (BSTT) constitute a heterogeneous group of neoplasms of mesenchymal and neuroectodermal origin. Although many BSTT are rare, it has become clear that BSTT are characterized by recurrent acquired chromosomal aberrations, and the general aim of this thesis have been to apply molecular genetic and molecular cytogenetic techniques to further characterize recurrent breakpoints and deletions, and to search for candidate target genes. READ MORE
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3. Trisomies in Hematologic Malignancies
Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE
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4. The clinical value of genetic analyses of bone and soft tissue tumors
Abstract : Tumors of bone and soft tissue are common but only constitute 1 % of all malignant tumors. The malignant tumors are often difficult to diagnose due to their rarity and morphological resemblance between subtypes. This makes the diagnostic process challenging. READ MORE
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5. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
Abstract : Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children 50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. READ MORE
