Search for dissertations about: "Avdelningen för klinisk genetik"
Showing result 6 - 10 of 91 swedish dissertations containing the words Avdelningen för klinisk genetik.
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6. Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies
Abstract : The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. READ MORE
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7. Tumour evolution and novel biomarkers in breast cancer
Abstract : Several gene signatures have been proposed in the past two decades to improve outcome prediction for breast cancer patients and to guide treatment decisions. Current treatment guidelines, however, primarily focus on established clinicopathological features. READ MORE
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8. Genetic factors affecting pregnancy duration in humans
Abstract : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. READ MORE
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9. Identification and characterization of candidate genes for neuroblastoma development
Abstract : Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features of NBs with unfavorable outcome is loss on distal chromosome 1p. READ MORE
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10. Epigenetic changes and immunological features of chronic obstructive pulmonary disease
Abstract : Background: Chronic obstructive pulmonary disease (COPD) is a heterogenous and chronic inflammatory syndrome with the lungs as its main target organ. Clinically, COPD is characterized by airflow limitation, chronic respiratory symptoms, and many extrapulmonary comorbidities. READ MORE