Search for dissertations about: "Axonal Guidance"

Showing result 6 - 10 of 16 swedish dissertations containing the words Axonal Guidance.

  2. 6. Cell therapy for spinal cord injury, studies of motor and sensory systems

    Author : Christoph Hofstetter; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nervous system; spinal cord injury; pseudorabies virus; axonal tracing; functional MRI; stereology; Rho-kinases; transplantation; stem cells; neurogenin2; allodynia;

    Abstract : Spinal cord injury represents a significant medical concern, affecting thousands of individuals each year. The majority of victims are young males harmed by traffic accidents, violence, and falls. Severe spinal cord injury interupts nerve fiber pathways connecting the brain and the rest of the body. READ MORE

  4. 7. Molecular determinants of endocannabinoid-mediated brain development

    Author : Daniela Calvigioni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The enchanting process of brain development entails a fragile and finite time window, throughout which biochemical imbalances and external insults can potentially affect developing neuronal circuits. Within the numerous exquisitely orchestrated events taking place in the foetal brain, axonal pathfinding is of paramount importance. READ MORE

  5. 8. Repair and Reconstruction of Peripheral Nerve Injuries. Treatment with G-CSF and Stromal Vascular Fraction

    Author : Hanna Frost; Malmö Handkirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injuries; nerve regeneration; reconstructive surgical procedures; diabetes mellitus; rat sciatic nerve; granulocyte colony-stimulating factor; stromal vascular fraction; electrospinning; rats; Schwann cells;

    Abstract : While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. READ MORE

  6. 9. Targeted gene transfer in the developing central nervous system using viral vectors

    Author : Simon Stott; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; Medicin människa och djur ; Medicine human and vertebrates ; gene transfer; in utero; neonatal; GDNF; nigrostriatal; dopamine; AAV; retrovirus; neuropsykologi; neurofysiologi;

    Abstract : Dopamine (DA) is a neurotransmitter that plays a fundamental role in many aspects of normal brain function. The majority of DA neurons in the brain reside in one region ? the midbrain ? and project axonal connections to specific areas. One of the main target regions of the DA system is the striatum. READ MORE

  7. 10. In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides

    Author : Joanne Bakker; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, helping neurons to mature and neuronal circuits to take form. READ MORE