Search for dissertations about: "Axonal Strain"

Showing result 1 - 5 of 11 swedish dissertations containing the words Axonal Strain.

2. 1. Definition of axonal injury tolerances across scales : A computational multiscale approach

   Author : Annaclaudia Montanino; Svein Kleiven; Alessandra Villa; Xiaogai Li; Kacy Cullen; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Traumatic Brain Injury; Axonal Injury; Mechanoporation; Multiscale;

   Abstract : Traumatic brain injury (TBI) is today regarded as a global health challenge. Revealing how external mechanical loads translate into tissue and cellular damage is necessary, not only for the development of better preventive measures, but also for the definition of treatments that could spare the patients from suffering TBI's devastating consequences. READ MORE

4. 2. Development of an Anisotropic Finite Element Head Model for Traumatic Brain Injury Prediction

   Author : Chiara Giordano; Svein Kleiven; Songbai Ji; KTH; []
   Keywords : Axonal Strain; Brain Anisotropy; Traumatic Brain Injury; Finite Element Analysis; Brain Tissue; Constitutive Modeling.; Medical Technology; Medicinsk teknologi;

   Abstract : Traumatic brain injury (TBI) is a worldwide health care problem with very high associatedmorbidity and mortality rates. In particular, the diagnosis of TBI is challenging: symptomsoverlap with other pathologies and the injury is typically not visible with conventionalneuroimaging techniques. READ MORE

5. 3. Finite Element and Neuroimaging Techniques toImprove Decision-Making in Clinical Neuroscience

   Author : Xiaogai Li; Svein Kleiven; Hans von Holst; Bernhard A Schrefler; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Traumatic brain injury; Intracranial Pressure; Brain edema; Gravitational force; Finite Element Model; Poroelastic parameter; Decompressive craniotomy; Image registration; Water content; Strain level; Diffusion Weighted Imaging;

   Abstract : Our brain, perhaps the most sophisticated and mysterious part of the human body, to some extent, determines who we are. However, it’s a vulnerable organ. When subjected to an impact, such as a traffic accident or sport, it may lead to traumatic brain injury (TBI) which can have devastating effects for those who suffer the injury. READ MORE

6. 4. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

   Author : Mariann Sondell; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

   Abstract : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. READ MORE

7. 5. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

   Author : Michael Jewett; Translationell Neurogenetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

   Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. READ MORE