Search for dissertations about: "B-ALL"
Showing result 11 - 15 of 21 swedish dissertations containing the word B-ALL.
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11. Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
Abstract : Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult myeloid AL (AML). READ MORE
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12. Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden
Abstract : Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records.I. READ MORE
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13. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer
Abstract : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. READ MORE
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14. MiRNAs in cancer
Abstract : There are many layers of complexity involving the processes through which somatic cells transform into malignant cancers. Historically, cancer was considered to be a disease primarily caused by gene mutations, however it is now well established that the dysregulated expression of the genes leading to the tumorigenic phenotype involves not only mutations but also epigenetic changes. READ MORE
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15. Long-Term Outcome of Fractures of the Thoracic and Lumbar Spine
Abstract : From the radiographic archives at the Malmö University Hospital, Malmö, Sweden, we identified children below age 16 years (n=74) and adolescents between 16 to 18 years (n=40) with a clinically and radiographically diagnosed thoracic or lumbar vertebral fracture between 1950 to 1971 (with exception of two years of missing radiographs), and all adults above age 18 years (n=39) with a non-operatively treated thoracic or lumbar burst fracture during the years 1965 to 1973. Fractures were classified according to Denis. READ MORE