Search for dissertations about: "B-cell malignancy"

Showing result 1 - 5 of 24 swedish dissertations containing the words B-cell malignancy.

  2. 1. B cell subsets in autoimmune disease

    Author : Katrin Habir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system and involved in creating immunological memory. B cells function in the humoral immune system by secreting antibodies which can bind pathogens to prevent them from doing further damage and to help other immune cells to target them. READ MORE

  4. 2. Biomarker Discovery in Cancer using Affinity Proteomics - Studies of B-cell lymphomas and Breast Cancer

    Author : Frida Pauly; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; cancer; B-cell lymphoma; breast cancer; biomarker discovery;

    Abstract : The continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. READ MORE

  5. 3. Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy

    Author : Qing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic leukemia (CLL). However, a sub-group of patients develops resistance to ibrutinib therapy. READ MORE

  6. 4. Novel imaging technology and tools for biomarker detection in cancer

    Author : Zahra El-Schich; Malmö högskola; []
    Keywords : Biomarkers; Kronisk lymfatisk leukemi; Early detection of cancer; Diagnosis; Leukemia; Lymphocytic; Chronic; B-Cell; Apoptosis; Digital holografi;

    Abstract : Cancer is a leading cause of death worldwide. Normally the balance betweencell growth and cell death is strongly controlled. Chronic lymphocytic leukemiais an indolent disease that has a highly variable clinical course and is the mostcommon hematological malignancy amongst adults in the Western countries. READ MORE

  7. 5. Molecular biological techniques as a tool in diagnostic pathology : Applications in B-cell lymphoproliferative disease, medullary thyroid carcinoma and cervical carcinoma

    Author : Mansour Alemi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; PCR-SSCP; MTC; RET mutation; Lymphoma; HPV; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Identification of malignancy associated with mutations in gene sequences requires detection ofas little as a single base difference. A powerful technique in mutation detection is polymerasechain reaction (PCR) followed by single-strand conformational polymorphism (SSCP) andsequencing. READ MORE