Search for dissertations about: "B-cell"

Showing result 21 - 25 of 571 swedish dissertations containing the word B-cell.

  2. 21. Innate mechanisms regulating peripheral B cell tolerance

    Author : Fredrik Wermeling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our immune system protects us from invading pathogens such as bacteria, viruses, fungi and parasites. However, it can also cause disease by being improperly activated against our own tissues (autoimmune diseases) and harmless environmental factors (allergy). READ MORE

  4. 22. Real-world studies on B-cell malignancies

    Author : Anna Asklid; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and regulatory agencies regarding recommendations as patients are strictly selected through inclusion- and exclusion criteria. READ MORE

  5. 23. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

    Author : Sarah Walsh; Richard Rosenquist; Christer Sundström; Anna Laurell; Andreas Rosenwald; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). READ MORE

  6. 24. To be or not to be, unraveling molecular mechanisms for lineage decisions in developing blood cells

    Author : Robert Månsson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; common lymphoid precursor CLP ; early B-cell factor 1 EBF1 ; B-cell; Stemcell; hematopoiesis; extracellulära vätskor; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : All hematopoietic cells originate from hematopoietic stem cells (HSC) residing in the BM. The process of differentiation, through which HSCs generate progenitors and subsequently mature blood cells has been extensively studied but many of the regulatory mechanisms involved remains elusive. READ MORE

  7. 25. Biomarker Discovery in Cancer using Affinity Proteomics - Studies of B-cell lymphomas and Breast Cancer

    Author : Frida Pauly; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; cancer; B-cell lymphoma; breast cancer; biomarker discovery;

    Abstract : The continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. READ MORE