Search for dissertations about: "BACHD"

Found 3 swedish dissertations containing the word BACHD.

  1. 1. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

    University dissertation from Department of Experimental Medical Science, Lund Univeristy

    Author : Sofia Hult Lundh; Lund University.; Lunds universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; depression; anxiety; metabolism; neuroendocrinology; mouse models; BACHD; rAAV vectors; leptin;

    Abstract : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. READ MORE

  2. 2. Neurochemical Signatures for the Evaluation of Disease State and Therapeutic Strategies in Neurodegenerative Diseases: a Magnetic Resonance Spectroscopy Study

    University dissertation from Lund University: Faculty of Medicine

    Author : Sandra Cuellar-Baena; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic Resonance Spectroscopy; neurochemical profile; neurodegenerative diseases; gene therapy.;

    Abstract : Magnetic Resonance Spectroscopy (MRS) allows for the quantification of neurotransmitters, antioxidants, energy-metabolism, membrane components and cellular viability markers present in the brain. This technology has been used in preclinical studies and later extended to be used in humans, where it offers an attractive non-invasive approach complementary to other anatomical imaging modalities (e. READ MORE

  3. 3. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease

    University dissertation from Lund University: Faculty of Medicine

    Author : Rana Soylu Kucharz; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s Disease; Huntingtin; Hypothalamus; Metabolism; Obesity; orexin; PVN; BAT; TH; neuroendocrinology;

    Abstract : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. READ MORE