Search for dissertations about: "BB Rat"

Showing result 1 - 5 of 17 swedish dissertations containing the words BB Rat.

  2. 1. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

    Author : Karina Åhlén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. READ MORE

  4. 2. Genetic Loci Contributing to Spontaneous Autoimmune Diabetes

    Author : Jessica Fuller; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Lymphopenia; BB Rat; Type 1 Diabetes; T Cell Receptor; Autoimmunity; Gimap;

    Abstract : Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for external manipulation. READ MORE

  5. 3. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Author : Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

  6. 4. Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods

    Author : Xiaojin Hao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; arteriogenesis; apoptosis; myocardial infarction; VEGF-A165; bFGF; PDGF-BB; adenovirus; plasmid; alginate;

    Abstract : Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the optimal application of growth factors and delivery method requires further exploration. READ MORE

  7. 5. Growth factors and their interaction in the regulation of vascular cells : with special reference to diabetes

    Author : Gunilla Dahlfors; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Proliferation of vascular smooth muscle cells plays an important role in the development of atherosclerosis and in restenosis following balloon angioplasty. This study focuses on growth factors associated with diabetic vascular disease and their interaction in the regulation of vascular smooth muscle cell growth. READ MORE