Search for dissertations about: "BCG"

Showing result 21 - 25 of 58 swedish dissertations containing the word BCG.

  2. 21. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer

    Author : Christina Ninalga; Thomas Tötterman; Magnus Essand; Timothy Ratliff; Uppsala universitet; []
    Keywords : Medicine; immunotherapy; bladder carcinoma; cancer; CpG ODNs; Adenoviral vector; CD40L; TRANCE; Lymphotactin; IL2; IL15; Medicin;

    Abstract : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. READ MORE

  4. 22. Effects of intestinal worms on skin immunity and control of co-infection

    Author : Cajsa Classon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Intestinal helminth infections remain a major health concern in developing areas of the world. Consequences of infection range from gastrointestinal discomfort to systemic manifestations. It has been suggested that individuals infected with intestinal helminths are more susceptible to other infections and mount weaker immunity to vaccination. READ MORE

  5. 23. Studies on the role of HIF-1 in the control of infection with Mycobacterium tuberculosis

    Author : Ruining Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), is responsible for most deaths caused by a bacterium globally. READ MORE

  6. 24. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Author : Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Abstract : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. READ MORE

  7. 25. Calcium signaling in development and disease

    Author : Marie Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The calcium ion (Ca2+) is a highly versatile signaling messenger involved in a diverse range of physiological processes such as gene transcription/expression, proliferation, differentiation and cell death. Intracellular Ca2+ signals are generated through a 10 000 – 20 000 fold gradient across the cell membrane and via release from the external milieu and/or internal Ca2+ stores. READ MORE