Search for dissertations about: "BETi"

Found 2 swedish dissertations containing the word BETi.

  1. 1. Using genetics to identify epigenetic and signal transduction targets in cancer

    University dissertation from Göteborg : University of Gothenburg

    Author : Joydeep Bhadury; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; BETi; HDACi; ATRi; miRNA; NGS; PDX; CDX;

    Abstract : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. READ MORE

  2. 2. Targeting Myc-driven tumours - BETing on ATR

    University dissertation from Göteborg : University of Gothenburg

    Author : Somsundar Veppil Muralidharan; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. READ MORE