Search for dissertations about: "BGP-15"

Found 5 swedish dissertations containing the word BGP-15.

  2. 1. Muscle Wasting in a Rat ICU Model : Underlying Mechanisms and Specific Intervention Strategies

    Author : Heba Salah; Lars Larsson; Sven Tågerud; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BGP-15; critical illness myopathy; janus kinase; intensive care unit; mechanical loading; muscle wasting; signal Transducer and Activator of Transcription; ventilator-induced diaphragm dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Clinical Neurophysiology; Klinisk neurofysiologi;

    Abstract : Critical care has undergone several developments in the recent years leading to improved survival. However, acquired muscle weakness in the intensive care unit (ICU) is an important complication that affects severely ill patients and can prolong their ICU stay. READ MORE

  4. 2. Critical illness myopathy : understanding different effects on muscle fibre function

    Author : Hannah Ogilvie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Skeletal muscle is an essential component of the human body, being one of the most dynamic and plastic tissues. As such it can be altered by numerous confounding factors. READ MORE

  5. 3. Critical illness myopathy : mechanisms and pharmacological interventions

    Author : Hazem Akkad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and speech. READ MORE

  6. 4. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Author : Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. READ MORE

  7. 5. The role of SUMO pathway in pathophsiology of skeletal muscle

    Author : Arvind Venkat Namuduri; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino acids. READ MORE