Search for dissertations about: "BMI-1"

Found 4 swedish dissertations containing the word BMI-1.

  1. 1. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy

    Author : Mohammad Alzrigat; Helena Jernberg-Wiklund; Fredrik Öberg; Kristina Drott; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Myeloma; Epigenetics; Polycomb; PRC2; PRC1; EZH2; BMI-1; UNC1999; PTC-209; Epigenetic Therapy; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Abstract : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. READ MORE

  2. 2. Investigating the role of neural stem/progenitor regulators in the context of brain tumor development

    Author : Isabelle Leefa Chong San; Stamcellscentrum (SCC); []
    Keywords : neural stem progenitor cells; regulators; brain tumor; cell of origin; cancer mechanisms;

    Abstract : Adult neural stem/progenitor cells (NSPs) are multipotent and self-renew over an extensive period of time. Transformation events in such cells, such as genetic or epigenetic alterations can result in brain tumors. READ MORE

  3. 3. Renal cell cancer : the role of physical activity and body size

    Author : Anna Bergström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis was to explore how physical activity, obesity, weight change, and birth weight influence the risk of renal cell cancer. The relation between occupational physical activity and risk of renal cell cancer was studied in a cohort of Swedish men and women identified in the nationwide censuses in 1960 and 1970, and followed for the occurrence of cancer by linkages to the Swedish Cancer Registry 1971-1989 (Paper I). READ MORE

  4. 4. Regulation of Hedgehog signalling during development and carcinogenesis

    Author : Marie Fiaschi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hedgehog (Hh) signalling is one of the most important signalling networks in the body and, when miss-regulated, has been implicated in many human tumours, particularly that of skin (Basal Cell Carcinoma, BCC) and brain (medulloblastoma). BCC most commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). READ MORE