Search for dissertations about: "BMI1"

Found 5 swedish dissertations containing the word BMI1.

  1. 1. HOST EPIGENETIC REGULATOR BMI1 AND VIRAL FIBER PROTEIN FOR EQUILIBRIUM BETWEEN ADENOVIRUS AND HOST

    University dissertation from Neurosurgery, Department of Clinical Sciences, Lund

    Author : Manli Na; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; BMI1; Dual-gene expression; Epigenetic; Equilibrium; Fiber; HSC; HDAC; TSA;

    Abstract : Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. READ MORE

  2. 2. Downstream effects of master regulators in two brain diseases

    University dissertation from Neurosurgery, Department of Clinical Sciences, Lund

    Author : Sebastian Braun; Lund University.; Lunds universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rett syndrome; brain tumor development; gene regulation; neural stem cells; cell of origin; BMI1;

    Abstract : In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in comparison to untreated mutant and to treated and untreated wild-type animals. READ MORE

  3. 3. Investigating the role of neural stem/progenitor regulators in the context of brain tumor development

    University dissertation from Lund University: Faculty of Medicine

    Author : Isabelle Leefa Chong San; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem progenitor cells; regulators; brain tumor; cell of origin; cancer mechanisms;

    Abstract : Adult neural stem/progenitor cells (NSPs) are multipotent and self-renew over an extensive period of time. Transformation events in such cells, such as genetic or epigenetic alterations can result in brain tumors. READ MORE

  4. 4. High resolution genomic tools for the discovery of protein function in mammalian cells

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Emily Carol Hodges; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-based assays; overexpression; RNAi; BC2; C3F; Taxol;

    Abstract : The work described in this thesis emphasizes the development of cell-based strategies with increased throughput design that enable rapid biological discovery through direct investigation of protein function. Each of the works represented in this thesis are unified by the common premise that genetic perturbations, through loss or gain-of-function, in cellbased models may serve as an entry point for assigning biological roles to uncharacterized genes and their gene products. READ MORE

  5. 5. Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation

    University dissertation from Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Author : Amir Nematollahi Mahani; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, cell cycle, differentiation and apoptosis. In general, Myc deregulation is a major prime force in human tumors, which contributes to their uncontrolled cell proliferation, metastasis and tumor cell immortalizations. READ MORE