Search for dissertations about: "BRAF"

Showing result 1 - 5 of 50 swedish dissertations containing the word BRAF.

  2. 1. Knowledge demanded for action : studies of knowledge mediation in organisations

    Author : Ewa Braf; Linköpings universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Computer science; Datavetenskap;

    Abstract : Knowledge enables action and is used in action, but organisations per se do not possess knowledge or perform actions. Organisations act through their members - human actors - who demand actionable knowledge to enable knowledgeable actions. READ MORE

  4. 2. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

    Author : Ida Lundberg; Richard Palmqvist; Maria Wikberg; Sofia Edin; Anita Sjölander; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; BRAF; KRAS; SOX2; CDX2; cancer stem cell; Th1 lymphocytes; miRNA; prognosis;

    Abstract : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. READ MORE

  5. 3. Clinical aspects of molecular profiles in metastatic malignant melanoma

    Author : Henrik Ekedahl; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanom; Prognos; BRAF; TERT; Genuttryck; Next generation sequencing; Melanoma; Prognosis; BRAF; TERT; Gene Expression; Next generation sequencing;

    Abstract : Malignant melanoma is a heterogeneous, malignant neoplastic disease, most often originating in the skin. Melanoma is characterized by a high mutational load and has a vastly variable prognosis, depending on disease stage. READ MORE

  6. 4. Metabolic Risk Factors and Molecular Subtypes of Colorectal Cancer

    Author : Robin Myte; Bethany van Guelpen; Richard Palmqvist; Jenny Häggström; Matty Weijenberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; risk factors; metabolic syndrome; one-carbon metabolism; molecular subtypes; KRAS; BRAF; MSI; molecular pathological epidemiology; Cancer Epidemiology; cancerepidemiologi;

    Abstract : Background: Colorectal cancer (CRC) is a heterogeneous disease developing from distinct pathways, resulting in tumor subtypes with large differences in clinical and molecular characteristics. Molecular characteristics are increasingly being used clinically to guide therapy. READ MORE

  7. 5. Understanding Cancer Mutations by Genome Editing

    Author : Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

    Abstract : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. READ MORE