Search for dissertations about: "BRAFV600E"
Showing result 1 - 5 of 10 swedish dissertations containing the word BRAFV600E.
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1. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
Abstract : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. READ MORE
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2. Clinical and epidemiological studies on prognostic and predicitve factors in cutaneous melanoma
Abstract : Background: Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in Sweden, as in many other western countries. In clinical practice, the histopathological evaluation has remained the basis for staging the CMMs and, thus, providing important information on prognosis and on therapeutic recommendations. READ MORE
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3. Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation
Abstract : Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common types of thyroid carcinoma, respectively. PTC patients generally have a good prognosis, although a subset of patients progress in their disease with poor clinical outcome. READ MORE
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4. Molecular studies in different types of melanoma tumors : correlations to clinical data
Abstract : Approximately 90% of melanomas arise from skin sites (known as cutaneous malignant melanoma; CMM), whereas the non-cutaneous melanoma (mucosal and ocular melanomas) are rare, accounting for about 10%. Familial melanoma accounts for up to 10% of patients diagnosed with CMM. Both genetics (e.g. READ MORE
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5. Understanding Cancer Mutations by Genome Editing
Abstract : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. READ MORE