Search for dissertations about: "BRCA"
Showing result 1 - 5 of 16 swedish dissertations containing the word BRCA.
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1. Genetic studies in familial non-BRCA breast cancer
Abstract : Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1, BRCA2 and other high- and moderate risk-genes account for 25% of the familial risk for breast cancer. READ MORE
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2. The Role of BRCA-1 and Nuclear Receptors in regulation of Neural Stem Cell Proliferation and Differentiation
Abstract : .... READ MORE
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3. Hereditary Ovarian Cancer mutation frequencies and genetic profiles
Abstract : Ovarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are diagnosed annually. Ovarian cancer has one of the highest frequencies of hereditary cancer. READ MORE
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4. Treatment of BRCA1/2-associated breast cancer and identification of mutation carriers among breast cancer patients
Abstract : The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer patients (n = 221). READ MORE
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5. Hormonal Regulation of Neural Stem Cell Proliferation and Fate Determination
Abstract : Stem cells have the capacity for both self renewal, and to form all cell types in the body. Interestingly, so called neural stem cells (NSCs) are found in the adult human brain, which is of significance both out of a developmental perspective and from a clinical point of view. READ MORE